Adrafinil is a precursor drug to Modafinil, which means adrafinil is metabolized in the body to produce modafinil. Both are stimulants with no amphetamine-like effects.
Molecular Weight: 289.35 g/mol
CAS Number: 63547-13-7
2-((diphenylmethyl)sulfinyl)-acetohydroxamicaci;2-((diphenylmethyl)sulfinyl)-n-hydroxy-acetamid;2-((diphenylmethyl)sulfinyl)-n-hydroxyacetamide;2-(benzhydrylsulfinyl)acetohydroxamicacid;ADRAFINIL;2-[(DIPHENYLMETHYL)SULFINYL]ACETOHYDROXAMIC ACID;CRL 40028;OLMIFON
Lafon Labs developed Adrafinil in the 1970s and it quickly became widely used in many European countries to improve wakefulness and for conditions that negatively impact the ability to stay awake. Now Adrafinil is more commonly recognized for its use as a mild stimulant; however, it does not function like your typical energy booster. Rather than causing hyperactivity, Adrafinil helps your body fight fatigue. It is much gentler than standard stimulants as it lacks most of the common side effects .
Adrafinil is also a prodrug for Modafinil, meaning that it leads to increased concentrations of Modafinil in your body. Modafinil is known for increasing alertness and preventing sleep; as a precursor, Adrafinil is similarly able to help you combat fatigue .
Adrafinil was discovered in the late 1970s by scientists working with the French pharmaceutical company Group Lafon. First offered in France in 1986 as an experimental treatment for narcolepsy, Lafon later developed modafinil, the primary metabolite of adrafinil. Even though the exact mechanism of action is unclear, "most investigators assume that adrafinil and modafinil both serve as α1-adrenergic receptor agonists." The evidence in support of this hypothesis is, however, weak and other mechanisms of action are probable. Modafinil possesses greater selective α1-adrenergic activity than adrafinil, without many of adrafinil's common side effects (stomach pain, skin irritation, anxiety and (with prolonged use) elevated liver enzymes). This makes it important to monitor the liver of an individual using adrafinil for prolonged periods.
As of September 2011, Cephalon has discontinued Olmifon, its adrafinil product.
Assists with ADHD symptoms
Aside from enhancing energy, Adrafinil has also been shown to improve cognitive function through an increase in mental focus, concentration, and memory. The beauty of Adrafinil's effects is that it is able to fight off fatigue without the negative jittery effects common to most stimulants. Quiet and reserved users have also reported feeling more open and talkative when taking Adrafinil .
Adrafinil's effects might not be immediately noticeable, as they typically build subtly over a period of several days to a few months . This is because Adrafinil selectively stimulates l-adrenergic receptors in the brain. Other stimulants affect a wide range of receptors in the brain leading to possible over stimulation. This is likely why Adrafinil typically has fewer negative side effects .
furous odor; it was synthesized by Louis Lafon Laboratories. The proprietary name of adrafinil is Olmifon®; its chemical name is (diphenylmethyl)sulfinyl-2-acetohydroxamic acid (see Fig. 1). This compound has a molecular weight of 289.35, and its empirical formula is C15H15NSO3. It has a melting point of 154°C with decomposition and is slightly soluble in water (< 1 g/L), more soluble in ethanol, and soluble in methanol. The synthesis of adrafinil is summarized in Fig. 1. Thiourea is reacted with bromodiphenylmethane over heat to produce diphenylmethane-thiol.Chloroacetic acid furous odor; it was synthesized by Louis Lafon Laboratories. The proprietary name of adrafinil is Olmifon®; its chemical name is (diphenylmethyl)sulfinyl-2-acetohydroxamic acid (see Fig. 1). This compound has a molecular weight of 289.35, and its empirical formula is C15H15NSO3. It has a melting point of 154°C with decomposition and is slightly soluble in water (< 1 g/L), more soluble in ethanol, and soluble in methanol. The synthesis of adrafinil is summarized in Fig. 1. Thiourea is reacted with bromodiphenylmethane over heat to produce diphenylmethane-thiol.Chloroacetic acid
Because of its strong anti-sleep effects, you should always take Adrafinil first thing in the morning to prevent trouble sleeping come bedtime . Effects from this supplement should be noticeable within 45 minutes to an hour of ingestion . A typical adrafinil dose is 300mg per day, but you should adjust accordingly depending upon your reaction to the substance and its effects.
As Adrafinil is metabolized by the liver, you may wish to supplement it with milk thistle to help minimize the impact on your liver from use.
There are theories to Adrafinil’s method of action, but its exact mechanism of action is not entirely clear. One popular theory is that it increases hypocretin, a brain neurotransmitter. Hyprocretin helps promote wakefulness, appetite and arousal. It is thought that one can increase their levels of norepinephrine, dopamine, and histamine by increasing the level of hypocretin in the hypothalamus. The increase of these three chemicals in the hypothalamus is thought to be the main nootropic action of adrafinil and modafinil. There is another possible method of action of adrafinil that is less popular than the above mentioned theory. The theory suggests that adrafinil and modafinil activate the glutamate pathways and inhibit the GABAeric pathways. This would lead to increased alertness and wakefulness.
Adrafinil and modafinil carry some degree of risk. Both substances can put an added strain on the heart and while it is less strenuous than typical amphetamines, there is still a substantial degree of risk. People with healthy hearts should not be as concerned however, in no way should one use adrafinil or modafinil if they have current or previous heart complications. Mixing adrafinil with other stimulants will greatly increase the chances of heart complications. SIDE EFFECTS：Anxiety，Irritability，Insomnia，Nausea，Dry Mouth