Caffeic acid phenethyl ester (CAPE) is a natural phenolic chemical compound. It is the ester of caffeic acid andphenethyl alcohol.
Synonyms：PHENETHYL 3,phenethyl caffeate
Formal Name：(E)-3-(3,4-dihydroxyphenyl)-2-propenoic acid, 2-phenylethyl ester
Molecular Weight: 284.31 g/mol
CAS Number: 104594-70-9
Solubility：Insoluble in water. Soluble in DMSO, or ethanol.
PHENYLETHYL CAFFEATE;PHENETHYL 3,4-DIHYDROXYCINNAMATE;PHENETHYL CAFFEATE;(E)-3-(3,4-
DIHYDROXYPHENYL)-2-PROPENOIC ACID, 2-PHENYLETHYL ESTER;CAFFEIC ACID PHENYLETHYL ESTER;CAFFEIC ACID PHENETHYL ESTER;2-phenylethyl3-(3,4-dihydroxyphenyl)-2-propenoate;3-(3,4-dihydroxyphenyl)-2-propenoicaci2-phenylethylester
Caffeic acid phenethyl ester (CAPE) is the active component of propolis, a honeybee hive product. Caffeic acid phenethyl ester is a specific inhibitor of the nuclear transcription factor, NF-κB. CAPE has been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation. Caffeic acid phenethyl ester inhibits HIV-1 integrase, and also inhibits proliferation of transformed cells. It induces apoptosis in transformed fibroblasts, and interferes with EGF signal transduction affecting both protein kinase C and ornithine decarboxylase activity.
CAPE is found in a variety of plants. It is also a component of propolis from honeybee hives.
Caffeic acid phenethyl ester is a specific inhibitor of the nuclear transcription factor NF-κB.