Mequinol is a drug used in combination with the drug tretinoin in the treatment of liver spots. Mequinol used alone and in higher doses is used as a topical drug for medical depigmentation.
A combination of mequinol 2% (depigmentation agent) & tretinoin 0.01% (topical retinoid) is commonly used in treating solar lentigines (liver spots & age spots). Exactly how it works is unknown, but this compound is used along with a total skin care and sunlight avoidance program. This compound may also be used for other conditions as determined by one's dermatologist. Methoxyphenol is a depigmentation agent, like Monobenzone (benzyloxyphenol), it is the active ingredient in some depigmenting creams and ointments. A formulation of 20% 4-methoxyphenol ointment causes depigmentation in animal tissue.
Lower dosages of topical mequinol and the Q-switched Ruby Laser have been used to depigment normal skin in vitiligo patients with disseminated (greater than 50 percent of body surface area) idiopathic vitiligo.