Pterostilbene is a stilbenoid chemically related to resveratrol. It belongs to the group of phytoalexins, agents produced by plants to fight infections.Based on animal studies it is thought to exhibit anti-cancer, anti-hypercholesterolemia, anti-hypertriglyceridemia properties, as well as the ability to fight off and reverse cognitive decline. It is believed that the compound also has anti-diabetic properties, but so far very little has been studied
on this issue.
Molecular Weight: 256.3 g/mol
CAS Number: 537-42-8
AKOS 236-80;3,5-DIMETHOXY-4'-HYDROXYSTILBENE;3',5'-DIMETHOXY-4-STILBENOL;4-[(1E)-2-(3,5-DIMETHOXYPHENYL)ETHENYL]PHENOL;PTEROSTILBENE;PTEROCARPUS MARSUPIUM;TRANS-3,5-DIMETHOXY-4'-HYDROXYSTILBENE;(E)-3,5-Dimethoxy-4'-hydroxystilbene
Pterostilbene is a stilbenoid related to resveratrol chemically, found in small amounts in blueberries and grapes. But the most cost effective source is from the bark and heartwood of a tree in India and Sri Lanka.
Pterostilbene is famous as its great effort to improve human health, fight against the diseases of aging and so on. Many benefits can be proved as below.
Pterostilbene for blood sugar and lipid metabolism and as Anti-Cancer Nutrient
Regarding the blood sugar and lipid metabolism, it can prevent elevated blood sugar and insulin resistance from a high fructose diet and can lower total cholesterol, triglycerides, and LDL- and VLDL-cholesterol in diet-induced hyperlipidemia.
With regards to anti-cancer effect, current study shows it can inhibit breast, prostate cancer, colon cancer, lung cancer, liver cancer and skin cancer.
Pterostilbene is not known to be toxic to humans so far and can be found on darker grapes having the highest concentrations among the fruit.
Pterostilbene is a double-methylated version of resveratrol exhibiting a higher bioavailability as it is more easily transported into the cell and more resistant to degradation and elimination.In rats, pterostilbene's oral availability is 67%-94%, and its half-life has been published to be between 78 minutes and 104 minutes.
Pterostilbene has anti-inflammatory, antineoplastic, and antioxidant actions via modulations of gene expression and enzyme activity. In plants the substance displays antifungal and antiviral activities.
In general, studies have focused on the trans isomer of pterostilbene.
Studies indicate that pterostilbene has antioxidant, anti-inflammatory and anti-cancer activity, lowers cholesterol and improves cognitive function.
Pterostilbene may help to prevent cancer. In-vitro studies demonstrate that pterostilbene induces apoptosis of cancer cells and improves the efficiency of the ant-cancer drug tamoxifen.
Improves heart health
Studies in test tube and animals show that pterostilbene may improve heart health by lowering cholesterol levels and reducing plaque formation.
Studies indicate the potential use of pterostilbene as an effective anti-inflammatory agent. The phytochemical inhibits the production of prostaglandin E2 from lipopolysaccharides-stimulated human blood cells.