Centrophenoxine is to DMAE like Alpha-GPC is to Cholinergic, an option that is better absorbed since the active molecule is bound to an absorption enhancer. Centrophenoxine carries the benefits of DMAE, and may boost Cognition in the elderly.
Molecular Weight: 294.17 g/mol
CAS Number: 3685-84-5
storage temp. −20°C
Centrophenoxine is a Cholinergic compound with a DMAE (Dimethylaminoethanol) component, and acts as a better absorbed transporter of DMAE into the brain. It is sold under the brand name Lucidril but can easily be bought over the counter or online.
It is effective in reversing some of the signs of aging (particularly waste product buildup in the brain) when taken for an acute period (high doses for a month) and can act as a general neural enhancer and protector when taken continuously at a lower dose.
In elderly patients, it has been clinically shown to:
have a mentally stimulating effect,
and improve general cognition.
used to treat Alzheimer’s disease patients
and senile dementia symptoms
There are many studies indicating the efficacy of centrophenoxine on aging, dementia, memory decline and Alzheimer’s, however, most involved animals which haven’t been replicated to humans. The following clinical trials are limited, warranting further research.
TARDIVE DYSKINESIA TREATMENT
The increased levels activities of dopamine and decreased levels or activities of choline are considered as the culprit of tardive dyskinesia. In order to measure the efficacy of centrophenoxine as a cholinergic agent, researchers of the current study orally administered meclofenoxate (600-1200 mg/day) to eleven participants with dystonia or tardive dyskinesia. Results revealed that 64% of the participants experienced slight to significant improvement. As such, meclofenoxate have potential positive effects on treating dyskinesias.
MEMORY LOSS IMPROVEMENT
A double-blind study involving healthy, elderly participants was carried out. Subjects were given centrophenoxine for a period of time. After the study period, they were assessed using specific memory performance measures and tests. Results of these tests revealed that centrophenoxine increases conversion of recent information into long-term memory. Subjective reports also suggested that it enhances mental alertness .
Another double-blind trial involving 50 individuals diagnosed with moderate dementia was performed. Subjects were initially treated with placebo for two weeks. Subsequently, they were given centrophenoxine for eight weeks. Laboratory tests were carried out after the two week placebo treatment. Results showed significant improvement. Psychometric test were improved and there was a significant improvement on intracellular water content signifying the anti-oxidant properties of centrophenoxine .
The anti-aging properties of centrophenoxine were further studied in a quantitative trial using the human glia cells. These cells were treated with centrophenoxine. Close study of the supplements effect revealed that it increase cell division by 30-40%. It also inhibits accumulation of potassium on said cells, thereby influencing cell mitotic division and cell metabolism which ultimately lead to delayed cellular aging .
Documented reports indicate that centrophenoxine has mild side effects which are generally tolerated by users. Other than this, it demonstrated its ability to treat certain memory problems and promote anti-oxidant properties. Additional research with larger sample human populations on this particular drug supplement is still needed however.
Centrophenoxine is primarily a cholinergic compound. It is structurally related to its parent molecule dimethylethanolamin/dimethyl amino ethanol (DMAE) – a naturally occuring substance that can be obtained from fishes and is considered to be more potent than the latter.
Chemical name/IUPAC: 2-Dimethylaminoethyl 4-chlorophynoxyacetate hydrochloride
Chemical formula: C12 H16 Cl NO3
Usage: anti-aging supplement; cognitive enhancer
The principal mechanism of action of centrophenoxine remains to be clouded with various hypotheses. Numerous hypotheses were studied and explained by researchers. These include:
INCREASE ACETYLCHOLINE LEVELS
It is thought that centrophenoxine promotes cholinergic activities. It produces choline and other essential phospholipids which are hereby converted to acetylcholine. With increased acetylcholine levels, brain plasticity or the communication between neurons is enhanced. This improvement leads to better neuromuscular control and memory formation.
ENHANCED OXYGEN AND GLUCOSE INTAKE
Centrophenoxine works through increasing the chemical activities and the overall functions of the brain. It exerts its function by improving oxygen and glucose absorption. As such, there is increased fuel to provide energy to the body and the brain.
Lipofuscin is the accumulation of potassium in the skin cells, lungs, heart and brain. Generally, this event is not dangerous; however, if a cell accumulates more potassium, it becomes less functional. As it is, the cell may even die. Lipofuscin accumulates in the body as time passes by; its symptoms are generally seen as aging. Centrophenoxine works by eliminating or decreasing the levels of lipofuscin/potassium build up in the body. As such, longevity and improved general body function is achieved. This is primary reason why centrophenoxine is considered as an anti-aging supplement.
INCREASE RNA PRODUCTION
Another mechanism of action associated with centrophenoxine is increased RNA production. Centrophenoxine increases essential proteins and RNA production necessary for normal cognitive functioning. RNA formation enables the neurons to develop essential proteins which can help in cell repair and memory enhancement.
Through these mechanisms of action, centrophenoxine has the ability to decrease the rate of brain functioning degeneration seen on dementia, brain damage, memory decline related to aging and Alzheimer’s disease. Additionally, it may help in eliminating free radicals in the body thereby reducing body and brain aging.
A clinical trial in which the mean age of the subjects was 64 revealed that over a 12 month time period, an extremely high daily dosage of 3 grams showed no harmful changes on the function of bone marrow and hepatic function.
Given DMAE’s theoretical teratogenic effects during early pregnancy through disruptions in choline metabolism, it would be prudent to avoid DMAE if trying to conceive .
Meclofenoxate is generally considered safe. However possible side effects may include nausea or mild dizziness. People with severely high blood pressure or convulsive disorders such as epilepsy should avoid meclofenoxate. Large doses may cause tight jaw clenching.
Oxiracetam, Piracetam, and Centrophenoxine stack
aniracetam +nefiracetam stack
Centrophenoxine and Piracetam stack
For therapeutic usage in reducing lipofuscin (for the aged) 3-6 doses of 250mg centrophenoxine is generally touted.
For younger individuals seeking neurological enhancement and neuronal protection, 1-3 doses of 250mg suffices.
The anti ageing system of centrophenoxine works by clearing the lipofuscin deposits that accumulate in the cells and body. Lipofuscin deposits are often the result of dark spots on the skin of older people that you may have noticed before.
Due to Centrophenoxine’s abilities to help in the regeneration and repairing of brain cells it is considered an vibrantly important drug in treatments concerning Senile Dementia and Alzheimer’s Disease. There are still many variables though that have to be looked at with improving cognitive abilities. As a result, it is very hard to determine just how effective Centrophenoxine would be for a specific person. It all comes down to their own needs and current cognitive ability as well as lifestyle choices.