Phenylpiracetam is a Nootropic derived from Piracetam, although it is fifty to sixty times more potent than its predecessor. This means you need a smaller Phenylpiracetam dosage to get the same great effects. The most beneficial effect relates to the formation and retention of long-term memory, magnified fluid intelligence, and enabling focus during debilitating mental tasks. Phenylpiracetam is a favored option for users seeking a more potent stimulant effect from their Nootropics, even though it is used less frequently than Piracetam or Pramiracetam.
Molecular Weight: 218.25 g/mol
CAS Number: 77472-70-9
Meclofenoxate (Lucidril), also known as centrophenoxine, is a drug used to treat the symptoms of senile dementia and Alzheimer's disease. It is an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA). DMAE is a natural substance, found especially in fish. pCPA is a synthetic compound that resembles a variety of plant hormones called auxins.
In elderly patients, it has been clinically shown to improve memory, have a mentally stimulating effect, and improve general cognition. Meclofenoxate also increases cellular membrane phospholipids.
It is also used off-label as a nootropic.
It is believed that Phenylpiracetam was developed in the early 1990’s in Russia. However, there is information dating back to 1983 in Soviet Journals. It is now becoming more popular and more accessible in the west.
It was later produced under the name ‘carphedon.’ It was mostly given to Russian military and astronauts to enhance their work. More recently, is has been used by athletes as a doping control, enhancing endurance. In 1998, it was added to the prohibited substance list for athletes.
In 2003, it was approved as a prescription drug within Russia. It is used to enhance cognitive and physical skills regarding memory and somatic issues. It is being researched as a treatment for stroke and epilepsy.
While there have not been many studies on phenylpiracetam in the West, those that have been done indicate that there is evidence that suggests it may be beneficial in a variety of circumstances. Some of these include increased cognitive function in terms of memory, alertness, and learning capacity, as well as the slowing of cognitive decline, such as that caused by aging. It is thought to have an ameliorating effect on depression (it has been shown to counteract the depressive side effects associated with benzodiazepine diazepam) and anxiety, and to improve physical stamina and cold tolerance (a quality that has made it a substance banned by the International Olympic Committee). Its more serious medical uses include the improvement of brain injury, types of glioma, cerebral lesions, and other encephalopathic conditions. It has also shown promise as an anti-convulsant and as a preventative measure for retrograde amnesia.
Synergistic With Racetams
So essentially, you get elevated levels of acetylcholine.
AND those increased levels are more effective, transmitting memory and learning messages quicker and creating stronger impressions in your brain.
AND those increased levels that are better, faster, and stronger are ALSO being metabolized from precursors quicker while remaining longer in the brain.
Carphedon is a derivative of piracetam. It is structurally comparable to its parent compound as well as on other piracetam derivatives (e.g. aniracetam, nefiracetam). A benzene (phenyl) ring was purportedly added on its structure to potentiate/enhance its effects more than that of piracetam. Phenylpiracetam can exist as two different enantiomers; nevertheless, it is typically used as a racemic compound. This nootropic agent has higher bioavailability and is quite more potent compared to other racetams.
Chemical name/IUPAC: (RS)-2-(2-oxo-4-phenylpyrrolidin-1-yl) acetamide
Chemical formula: C12H14N2O2
Professor ZS Nagy conducted a double blind trial of 50 elderly patients with severe Alzheimer’s Disease, averaging around age 76. He noted a significant increase in mental and physical performance in 50 percent of all these patients, which means it is very effective.
Another study involved around 75 elderly subjects who were noted as healthy, however suffered from significant intellectual deterioration, found that Centrophenoxine increased storage of new information into long term memory, while also increasing focus, vigilance and alertness. This was noted after only a few short weeks of supplementation.
The mechanism of action of phenylpiracetam is unclear. However, in a recent study done by Basic and Clinical Pharmacology and Toxicology, an investigation of carphedon’s “stereoselective pharmacological activity” was carried out. This study tried to explain how it works and how it is different from other piracetam like drugs.
Phenylpiracetam can be separated into two different enantiomers – R- and S- enantiomer. The S- enantiomer is claimed to be responsible on leviteracetam’s anti-convulsant action. This study revealed that R- enantiomer was the most active substance found in phenylpiracetam exerting significant effects on memory improvement, locomotor activities (e.g. muscle strength, motor coordination) and anti-depressant activities through increasing the density of nicotinic acetylcholine, GABA, dopamine and N-methyl-D-aspartate receptors. These receptors are involved in memory and overall cognition process
Meclofenoxate is generally considered safe. However possible side effects may include nausea or mild dizziness. People with severely high blood pressure or convulsive disorders such as epilepsy should avoid meclofenoxate. Large doses may cause tight jaw clenching.
It is recommended that you take 100-200 mg doses, two to three times daily. This means a daily intake of 200-600 mg. The lower range is effective and should be taken for first time users. Anytime you’re trying something new, the lowest dose is always recommended. Speak to your doctor before starting usage.
Some users will only take 100 mg daily as it is so effective. Break this dosage up into two doses; one in the morning and one in the afternoon. Also, be aware that Phenylpiracetam will build tolerance levels. Therefore, it should not be taken every day, but on a cycle or when needed. For example, take it a few times one week, then take a few weeks off.