N-[2-(diisopropylamino)ethyl]-2-oxo-1-pyrrolidineacetamide powderN-[2-(diisopropylamino)ethyl]-2-oxo-1-pyrrolidineacetamide powder
N-[2-(diisopropylamino)ethyl]-2-oxo-1-pyrrolidineacetamide powder
N-[2-(diisopropylamino)ethyl]-2-oxo-1-pyrrolidineacetamide powder

N-[2-(diisopropylamino)ethyl]-2-oxo-1-pyrrolidineacetamide powder

Product Code: CAS:68497-62-1
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Product Summary:

Pramiracetam is a central nervous system stimulant and nootropic agent belonging to the racetam family of drugs. It is used in Eastern European countries and has the brand names Remen (Parke-Davis), Neupramir (Lusofarmaco), or Pramistar (Firma).

Pramiracetam powder is a nootropic drug that is derived from piracetam, but is much more potent. Pramiracetam is tolerated well by humans, like other drugs in the racetam family.

In one study of human subjects with Alzheimer disease of varying degrees, their Alzheimer’s symptoms were mild and few after receiving Pramiracetam treatments for just 5–8 weeks.

Product Description

Synonyms:Pramiracetam

Formal Name:Amacetam;NeupraMir;PraMistar;ReMen;Vinpotropil

Formula   C14H27N3O2

Molecular Weight: 269.38 g/mol

Purity        ≥99%

CAS Number: 68497-62-1

Other names:

Amacetam, CI-879, N-[2-(Diisopropylamino)ethyl]-2-(2-oxopyrrolidin-1-yl)acetamide, N-[2-(Diisopropylamino)ethyl]-2-oxo-1-pyrrolidineacetamide, N-[2-Bis(1-methyl-ethyl)amino)ethyl]-2-oxo-1-pyrrolidineacetamide, Neupramir, Pramiracetamum, Pramistar (Latvia, Lithuania, Romania), Remen

What Is Pramiracetam?

Pramiracetam is a synthetic racetam derivative for the purpose of cognitive enhancement, with preliminary evidence to support its usage in aiding long-term memory formation. Although the mechanisms are not well known at all, it might enhance acetylcholine synthesis.

Pharmacokinetics

Pharmacokinetic rules of pramiracetam were studied here. After giving pramiracetam orally to dogs, we drew their blood at various times. The drug concentrations in blood plasma were detected by HPLC. 3p87 program was used to calculate the pharmacokinetic parameters. The time-concentration curve corresponded to one apartment model. T1/2 was about 2.3-3.9 hours in various doses. After pramiracetam was given to rats per os, high concentrations of pramiracetam were detected in the rats' tissues. The kidney had the highest concentration of pramiracetam; the liver had the next highest concentration, and then the intestine, lung, muscle, heart, gonad, spleen and sebum had the high concentration in order. The drug was also detected in the brain. 0.7% of the given dose was excreted in unchanged form in bile in 24 hours. 28.26% and 6.35% were excreted in urine and feces respectively in 72 hours. The plasma protein combining rate detected by the method of balance dialysis was 20.1-22.2%.

Pramiracetam USES

Increase of cerebral blood flow

Increase in long term memory

Increase cerebral blood flow

Improve Long-Term Memory Functioning

Aids Advanced Technical and Logical Thinking

Benefits Of Pramiracetam

Although pramiracetam is considered to be unique amongst its kind, it demonstrates similar racetam effects. It is generally tolerated by the human body with minimal side effects. Additionally, effects are seen half to an hour immediately after administration since it reaches its peak plasma concentration on the next three to four hours. As such, it is often used off-label in a wide array of medical applications. Human trials were carried out by many researchers to show its beneficial effects on various medical problems.

Pramiracetam Chemical Structure

Pramiracetam is fat soluble unlike aniracetam, oxiracetam and piracetam. It is easily absorbed by the gastrointestinal tract which is the reason why it is more potent than any other racetam. Structurally, it is similar to piracetam; however, the amide group of its parent molecule is replaced with dipropan-2-ylaminoethyl group.

Chemical Name/ IUPAC: Diisoprop-yl-(2-oxopyrrolidin-1-yl)acetamide

Chemical formula: C14H27N3O2

Usage: Nootropic agent, cognitive enhancer

Pramiracetam Directions

Pramiracetam powder is water soluble. Do not use if you are pregnant or breastfeeding.

Store in a cool, dry place, away from excess light. Once opened, keep the product in the original packaging and the compounds will stay fresh for many years.

Pramiracetam Mechanism of Action

Pramiracetam is known under the chemical name, [N-[2-[bis(1-methylethyl)amino]ethyl]-2 oxo-1-pyrrolidineacetamide sulfate]. It is one of the newer nootropics in the racetam chemical class and has a similar method of action to other racetams. It is believed to influence the Glutamate (Cholinergic) and specifically, the ACh (Acetylcholine) receptor sites by improving reuptake and the efficiency of their channels.

Unlike Aniracetam and Noopept, Pramiracetam does not seem to influence the dopaminergic or serotonin (5HT) receptor sites. Instead, Pramiracetam seems to have a high affinity in influencing choline uptake into the hippocampus. Other areas of the cerebral cortex do not seem to be affected by the chemical. Pramiracetam is believed to strictly influence acetylcholine uptake and channel specific nerve impulses in the hippocampus.

Pramiracetam has a very specific method of action in hippocampal Acetylcholine turnover. It may be a common culprit for causing headaches and fatigue because of ACh receptor “burn out“. A common way to avoid this would be to supplement with Alpha GPC in order to increase the level of bioavailable acetylcholine. This is just a theory but studies have shown Pramiracetam to have a specific function on these hippocampal ACh receptors.

Pramiracetam Safety and Side Effects

At relatively low dosages, a few participants reported headaches. One participant at the highest end of the dosage spectrum experienced sleepiness, decreased appetite, and dizziness.

In another study where a small sample of healthy, male human subjects were treated for 10 days, no adverse events were reported.

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